Exchange stops working due to diskspace

Try using following if issue is low disk space on system drive, this will come as a backpressure alert
  1. Open the following file by using Notepad:

    C:\Program Files\Microsoft\Exchange Server\Bin\EdgeTransport.exe.config.

  2. Modify the following line in the <appSettings> section:
    <add key="QueueDatabasePath" value="<LocalPath>" />

    For example, to create a new location for your transaction logs at the location “C:\Queue\QueueDB”, modify the QueueDatabasePath parameter as follows:

    <add key="QueueDatabasePath" value="C:\Queue\QueueDB" />
  3. Save and close the EdgeTransport.exe.config file.
  4. Restart the Microsoft Exchange Transport service.
  5. Verify that the new Mail.que and Trn.chk files are created at the new location.
  6. Remove the unused Mail.que and Trn.chk files from the original location.

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